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Research
Dr. Petroski studies how proteins are modified with ubiquitin and ubiquitin-like proteins.
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Biography
Dr. Petroski earned his Ph.D. in Biochemistry and Molecular Biology from the University of California, Irvine.
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.
Petroski MD, Zhou X, Dong G, Daniel-Issakani S, Payan DG, Huang J
J Biol Chem. 2007 Oct 12;282(41):29936-45
Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex.
Petroski MD, Kleiger G, Deshaies RJ
Mol Cell. 2006 Nov 17;24(4):523-34
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.
Petroski MD, Deshaies RJ
Cell. 2005 Dec 16;123(6):1107-20
Function and regulation of cullin-RING ubiquitin ligases.
Petroski MD, Deshaies RJ
Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20
Context of multiubiquitin chain attachment influences the rate of Sic1 degradation.
Petroski MD, Deshaies RJ
Mol Cell. 2003 Jun;11(6):1435-44
View All Publications
Matthew Petroski's Research Focus
Cancer, Breast Cancer, Leukemia/Lymphoma, Lung Cancer, Myeloma
Our lab focuses on understanding how proteins are modified with ubiquitin and ubiquitin-like proteins. We anticipate that understanding how the ubiquitin system functions and regulates cellular processes will lead to the development of therapeutics that will have broad impact on human health. Alterations in protein function controlled by specific pathways of the ubiquitin system are associated with cancer, inflammation, neurodegenerative diseases, and viral infection. We aim to dissect and study these important pathways using a combination of cell biology, molecular genetics, biochemistry, proteomics, and chemical biology.
Our current interests include:
1. mechanisms of ubiquitin chain synthesis and protein modification
2. cellular functions of the ubiquitin-like protein NEDD8 in regulating cullin-RING ubiquitin ligases
3. ubiquitinated protein recognition and delivery to the 26S proteasome
About Matthew Petroski
Experience
Matthew Petroski earned his Ph.D. in Biochemistry and Molecular Biology from the University of California, Irvine, and was a Jane Coffin Childs Fellow and HHMI post-doctoral fellow from 1999-2005 with Ray Deshaies at Caltech. From 2005-2007, Matt was a Research Scientist at Rigel Pharmaceuticals, Inc. in South San Francisco and was recruited to Sanford-Burnham Medical Research Institute as an Assistant Professor in December 2007.
Education
Ph.D., University of California Berkeley, Molecular Biology & Biochemistry, 1999
B.A., University of California, Berkeley, Molecular Cell Biology Genetics, 1993
Honors and Recognition
American Cancer Society Research Scholar
V Foundation for Cancer Research Scholar
Jane Coffin Childs Memorial Fund for Medical Research Fellow
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