"Hope lies in dreams, in imagination and in the courage of those who dare to make dreams into reality." -Jonas Salk. I do what I do because I believe that our integrative studies on the hypothalamus will lead to significant discoveries that will positively impact modern medicinal treatment for obesity, and perhaps other disease states. The unique visionary research environment of the Sanford-Burnham Medical Research Institute enables researchers, like myself, to translate our scientific discoveries to therapeutic realities.
Dr. Altarejos studies how peripheral signals modulate energy balance through the regulation of gene expression in the hypothalamus.
Dr. Altarejos earned her Ph.D. in Medical Sciences from the University of Alberta, Canada.
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CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
Altarejos JY, Montminy M
Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51
CRTC3 links catecholamine signalling to energy balance.
Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, CHARGE Consortium, GIANT Consortium, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M
Nature. 2010 Dec 16;468(7326):933-9
Adipocyte CREB promotes insulin resistance in obesity.
Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T, Olefsky J, Montminy M
Cell Metab. 2009 Mar;9(3):277-86
The Creb1 coactivator Crtc1 is required for energy balance and fertility.
Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M
Nat Med. 2008 Oct;14(10):1112-7
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M
Science. 2006 Jun 23;312(5781):1763-6
The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines.
Csont T, Viappiani S, Sawicka J, Slee S, Altarejos JY, Batinić-Haberle I, Schulz R
J Mol Cell Cardiol. 2005 Nov;39(5):833-40
Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase.
Altarejos JY, Taniguchi M, Clanachan AS, Lopaschuk GD
J Biol Chem. 2005 Jan 7;280(1):183-90
gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts.
Onay-Besikci A, Altarejos JY, Lopaschuk GD
J Biol Chem. 2004 Oct 22;279(43):44320-6
Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.
Sambandam N, Steinmetz M, Chu A, Altarejos JY, Dyck JR, Lopaschuk GD
Eur J Biochem. 2004 Jul;271(13):2831-40
Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase.
Shields DJ, Altarejos JY, Wang X, Agellon LB, Vance DE
J Biol Chem. 2003 Sep 12;278(37):35826-36
Judith Altarejos's Research Focus
Diabetes - General, Metabolic Syndrome, Obesity, Type 2 Diabetes, Metabolic Diseases
Watch Dr. Altarejos discuss her research
Obesity is a major risk factor for the development of several diseases including type 2 diabetes, cardiovascular disease and certain types of cancer. Obesity - defined as the excessive accumulation of fat - arises from an imbalance between energy intake and energy expenditure. Our ultimate goal is to understand the physiological, cellular and molecular circuits that coordinately modulate appetite and energy expenditure. By studying these regulatory circuits, we hope to discover the causes of energy imbalance that lead to obesity and establish a foundation for the development of novel therapeutics for the treatment of obesity.
About Judith Altarejos
Judith Altarejos, Ph.D., earned her doctorate in Medical Sciences from the University of Alberta, Canada. During her doctoral training with Dr. Gary Lopaschuck at the University of Alberta, she studied the regulation of energy metabolism in the heart. Dr. Altarejos continued her training as a postdoctoral fellow in Dr. Marc Montminy's laboratory at the Salk Institute, where she researched appetite control and adipose tissue metabolism. In 2011, Dr. Altarejos joined Sanford-Burnham as an Assistant Professor in the Metabolic Signaling and Disease Program.
Ph.D., Medical Sciences, University of Alberta, Edmonton, Canada, 2005
Research Associate, Peptide Biology, Salk Insitute, San Diego, California, 2011