Dr. Price's laboratory develops fully automated, quantitative microscopy, or scanning cytometry, for biomedical applications.
Dr. Price received his M.D. from Loma Linda University and his Ph.D. in bioengineering from UC San Diego.
Hybrid median filter background estimator for correcting distortions in microtiter plate data.
Bushway PJ, Azimi B, Heynen-Genel S, Price JH, Mercola M
Assay Drug Dev Technol. 2010 Apr;8(2):238-50
Exploration of chromatic aberration for multiplanar imaging: proof of concept with implications for fast, efficient autofocus.
Weinigel M, Kellner AL, Price JH
Cytometry A. 2009 Dec;75(12):999-1006
Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes.
Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, Price JH, Conklin BR, Chen HS, Mercola M
PLoS One. 2009;4(4):e5046
A comparative analysis of standard microtiter plate reading versus imaging in cellular assays.
Bushway PJ, Mercola M, Price JH
Assay Drug Dev Technol. 2008 Aug;6(4):557-67
Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy.
Shen F, Hodgson L, Price JH, Hahn KM
Cytometry A. 2008 Jul;73(7):658-66
Filtering out contrast reversals for microscopy autofocus.
Oliva MA, Bravo-Zanoguera M, Price JH
Appl Opt. 1999 Feb 1;38(4):638-46
Dynamic autofocus for continuous-scanning time-delay-and-integration image acquisition in automated microscopy.
Bravo-Zanoguera ME, Laris CA, Nguyen LK, Oliva M, Price JH
J Biomed Opt. 2007 May-Jun;12(3):034011
Plasma membrane assays and three-compartment image cytometry for high content screening.
Prigozhina NL, Zhong L, Hunter EA, Mikić I, Callaway S, Roop DR, Mancini MA, Zacharias DA, Price JH, McDonough PM
Assay Drug Dev Technol. 2007 Feb;5(1):29-48
Functional proteometrics for cell migration.
Shen F, Hodgson L, Rabinovich A, Pertz O, Hahn K, Price JH
Cytometry A. 2006 Jul;69(7):563-72
Statistics of assay validation in high throughput cell imaging of nuclear factor kappaB nuclear translocation.
Morelock MM, Hunter EA, Moran TJ, Heynen S, Laris C, Thieleking M, Akong M, Mikic I, Callaway S, DeLeon RP, Goodacre A, Zacharias D, Price JH
Assay Drug Dev Technol. 2005 Oct;3(5):483-99
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Differential Phosphorylation of Perilipin 1A at the Initiation of Lipolysis Revealed by Novel Monoclonal Antibodies and High Content Analysis.
McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH
PLoS One. 2013;8(2):e55511
Jeffrey Price's Research Focus
The central theme is creation of high performance of image cytometry (AKA, quantitative microscopy, digital pathology, high content screening / assays – HCS/A) instrumentation and algorithms. The instrumentation focus areas include high performance autofocus, high-speed scanning, 3D cytometry and high throughput confocal microscopy. We apply these advances to: genomic and compound HCS/A (for early drug discovery and toxicity); kinetics of fast cellular events (including muscle contraction, cardiomyocyte arrhythmogenicity, neuron action potentials, β-cell insulin release); tracking of cell migration, development/differentiation and cancer progression; ultra-rare circulating tumor cell biology; and histology of cancer biomarkers.
About Jeffrey Price
Jeffrey H. Price received his M.D. degree from Loma Linda University, Loma Linda, CA, in 1985, and his Ph.D. degree in bioengineering from the University of California, San Diego, in 1990, where he also received his postdoctoral training. In 1993, he was appointed Assistant Project Scientist and, in 1996, Associate Research Scientist. From 1994 to 2004 he directed the NSF-Whitaker Quantitative Imaging and Confocal Microscopy Resource in Bioengineering at UCSD. In 1999 he founded Q3DM, Inc., which marketed his research group’s high throughput microscopy inventions for cell-image-based screening, and which was purchased by Beckman Coulter, Inc. in 2003. In 2004 he Co-Founded Vala Sciences Inc, which develops and markets software and kits for cell-image based assays. He was recruited to the position of Associate Professor at Sanford-Burnham Medical Research Institute in 2004, where he is a member of the Signal Transduction and Stem Cells and Regeneration Research Programs.
Ph.D., University of California, San Diego, Bioengineering, 1990
M.S., University of California, San Diego, Bioengineering, 1988
M.D., Loma Linda University, Medicine, 1985
B.S., University of Southern California, Biomedical (Elec.) Engineering, 1981