Dr. Chen studies the factors controlling development, maturation and function of various ion channels in cardiac and neurological system.
Dr. Chen earned his Ph.D. in Biological Chemistry and Molecular Pharmacology at Harvard Medical School in 1993.
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.
Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3943-8
NR3A modulates the outer vestibule of the "NMDA" receptor channel.
Wada A, Takahashi H, Lipton SA, Chen HS
J Neurosci. 2006 Dec 20;26(51):13156-66
The chemical biology of clinically tolerated NMDA receptor antagonists.
Chen HS, Lipton SA
J Neurochem. 2006 Jun;97(6):1611-26
Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.
Choi Y, Chen HV, Lipton SA
J Neurosci. 2001 Jan 15;21(2):392-400
Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation.
Choi YB, Tenneti L, Le DA, Ortiz J, Bai G, Chen HS, Lipton SA
Nat Neurosci. 2000 Jan;3(1):15-21
Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism.
Chen HS, Lipton SA
J Physiol. 1997 Feb 15;499 ( Pt 1):27-46
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor.
Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA
Neuron. 1994 Oct;13(4):929-36
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS
Nature. 1993 Aug 12;364(6438):626-32
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity.
Chen HS, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA
J Neurosci. 1992 Nov;12(11):4427-36
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Missense mutations in plakophilin-2 can cause brugada syndrome phenotype by decreasing sodium current and nav1.5 membrane localization.
Cerrone M, Lin X, Zhang M, Agullo-Pascual E, Pfenniger A, Chkourko Gusky H, Novelli V, Kim C, Tirasawadischai T, Judge DP, Rothenberg E, Chen HV, Napolitano C, Priori SG, Delmar M
Heart Rhythm. 2013 Nov;10(11):1743
Huei-Sheng Vincent Chen's Research Focus
Cardiovascular Diseases, Heart Disease, Neurodegenerative and Neuromuscular Diseases, Stroke
Dr. Chen’s laboratory focuses on the electrophysiological and metabolic maturation/ development of mouse embryonic hearts and human stem cell-derived cardiomyocytes. During cardiac development, various nonmyocardial cells control or guide electrical/ metabolic maturation of embryonic mouse hearts and primitive cardiomyocytes derived from human embryonic stem cell or induced pluripotent stem cell lines. The Chen laboratory has established several co-culture systems of human stem cell-derived cardiomyocytes with cells derived from neural crest or endothelial progenitor cells so as to elucidate factors from non-cardiomyocytes that induce electrical maturation of primitive cardiomyocytes. The main emphasis of Chen laboratory is placed on the neuro-cardiac interactions, which affect embryonic cardiac development and contribute to arrhythmogenesis, such as atrial fibrillation in adult humans.
The Chen laboratory also has successfully established several cardiac disease-specific induced pluripotent stem cells (iPSC) lines from human fibroblasts of patients with arrhythmogenic diseases, such as Arrhythmogenic Right Ventricular Cardiomyopathy/ Dysplasia, Hypertrophic Cardiomyopathy, Catecholaminergic Polymorphic Ventricular Tachycardia, and Kearns-Sayre syndrome to model human cardiac diseases in a dish. Using maturation induction techniques developed in the Chen laboratory, Chen’s team has started to unravel the electrical and metabolic derangement underlying these inherited arrhythmogenic cardiac diseases. New pathogenic pathways have been identified with these in-vitro human disease models, enabling mechanistic studies and therapeutic screens to develop safe and effective therapeutic strategies for these lethal cardiac diseases.
About Huei-Sheng Vincent Chen
Huei-Sheng Vincent Chen earned his Ph.D. in Biological Chemistry and Molecular Pharmacology at Harvard Medical School in 1993 and his B.M. (M.D. equivalent) at College of Medicine, National Taiwan University. He completed residency training in Internal Medicine at Brigham and Women’s Hospital, Harvard Medical School. He then completed his Cardiology and Cardiac Electrophysiology fellowship at the Beth-Israel Deaconess Medical Center, Harvard Medical School. He received postdoctoral training in Dr. Stephen Heinemann’s Laboratory at The Salk Institute and cardiac electrophysiology training with Dr. Mark Josephson and Dr. Gregory Feld. Dr. Chen was recruited to Sanford-Burnham Medical Research Institute as assistant professor in 2002.