Gregory Roth

Gregory Roth, Ph.D.[Lake Nona in Orlando]

  • Director, Medicinal Chemistry
  • Research

    Roth’s research interests focus on advancing novel synthetic methods and technologies for the generation of compound screening libraries.

  • Biography

    Dr. Roth earned his Ph.D. in Chemistry at Colorado State University in 1988.

Publications

 

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Gregory Roth's Research Focus

Cancer, Cardiovascular Diseases, Inflammatory/Autoimmune Disease, Metabolic Diseases, Aging-Related Diseases, Neurodegenerative and Neuromuscular Diseases

Gregory P. Roth, Ph.D., Associate Professor and Director of Medicinal Chemistry at Sanford-Burnham Medical Research Institute at Lake Nona, has 23 years of post-graduate pharmaceutical industry leadership experience and scientific accomplishments in the areas of Process Research, Combinatorial Chemistry and Medicinal Chemistry. Dr. Roth’s research interests focus on advancing novel synthetic methods and technologies for the generation of compound screening libraries based on natural product motifs.

Dr. Roth’s current work centers on the discovery of new chemical 'tools' in the areas of chemical biology and medicinal chemistry designed to answer significant biochemical questions in disease areas of unmet medical need. Currently, Dr. Roth’s lab is identifying and exploring the synthesis of enhanced analogs of several newly discovered natural product molecules which demonstrate properties that may be beneficial to the treatment of specific cancer types.

About Gregory Roth

Experience

Gregory P. Roth, Ph.D., holds 16 patents awarded or pending and has authored more than 60 research papers. Dr. Roth earned graduate degree in Chemistry at Colorado State University in 1988 under the direction of the late Professor A.I. Meyers. Dr. Roth also holds a Bachelor of Science (1979) and a Master of Science (1984) in Chemistry achieved at the State University of New York College at Fredonia in 1984. Prior to joining Sanford-Burnham in 2007 as an academic research investigator, Dr. Roth had over 20 years of pharmaceutical industry leadership and has contributed to drug discovery and development research programs at Bristol-Myers Squibb, Boehringer Ingelheim Pharmaceuticals and the Abbott Bioresearch Center. He is also a co-founder of Electra Pharmaceuticals, an emerging biotechnology company that is advancing natural products as therapeutics in the area of neurodegenerative disease.

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Education

Doctorate of Philosophy in Chemistry; Colorado State University; June 1984-September 1988
Advisor: Albert I. Meyers, Ph.D.
Dissertation Title: Asymmetric Tandem Additions to Naphthyloxazolines: Methods and Applications.

Master of Science in Chemistry; State University of New York at Fredonia; August 1982-May 1984.
Advisor: James R. Bowser, Ph.D.
Thesis Title: Directed Metallation Studies of 1,3-Bis(imidazolidinyl)benzene.

Bachelor of Science in Chemistry and Biology; State University of New York at Fredonia; August 1976-May 1979
Undergraduate Research Advisor: Thomas D. Harris, Ph.D.

Other Appointments

Electra Pharmaceuticals
co-Founder and Scientific Advisory Board Member, June 2010 to present

University of Florida-Gainesville
Adjunct Associate Professor, Medicinal Chemistry-College of Pharmacy, September 2010 to present

Orlando Museum of Art (OMA) 'Art's the Spark'
Advisory Committe Member, May 2011-Present

Boston University, Department of Chemistry and NIH Center for Methodology and Library Development
NIH-CMLD Scientific Advisory Board Member and Consultant, August 2002-August 2009
Adjunct Professor of Chemistry, September 2000-March 2007

American Chemical Society
Orlando Section Chair, January 2010-December 2010
Orlando Section Chair-Elect, January 2009-December 2009

H. Lee Moffitt Cancer Center
External Advisory Board Member (NIH P01 Drug Discovery Program), January 2009 to January 2011

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