Dr. Wolf's research focuses on the postranscriptional regulation of tumor-suppressor protein abundance and function.
Dr. Wolf obtained an M.D. degree from the Ludwig-Maximilian’s University in Munich, Germany in 1995.
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Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.
Keren-Kaplan T, Attali I, Motamedchaboki K, Davis BA, Tanner N, Reshef Y, Laudon E, Kolot M, Levin-Kravets O, Kleifeld O, Glickman M, Horazdovsky BF, Wolf DA, Prag G
EMBO J. 2012 Jan 18;31(2):378-90
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
Petroski MD, Salvesen GS, Wolf DA
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1749-50
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.
Rico-Bautista E, Yang CC, Lu L, Roth GP, Wolf DA
BMC Biol. 2010;8:153
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.
Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA
Mol Cell. 2009 Oct 9;36(1):141-52
F-box-directed CRL complex assembly and regulation by the CSN and CAND1.
Schmidt MW, McQuary PR, Wee S, Hofmann K, Wolf DA
Mol Cell. 2009 Sep 11;35(5):586-97
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP
Nat Cell Biol. 2009 Sep;11(9):1157-63
Dieter Wolf's Research Focus
Our research focuses on basic posttranscriptional mechanisms that control protein abundance and function. We concentrate on conserved pathways regulating protein synthesis at the level of translation and protein degradation through the ubiquitin-proteasome system. For many of these studies, we are using the fission yeast Schizosacharomyces pombe as a model system. Our studies also employ a variety of genome-wide approaches such as proteomics and ribonomics. Our goals are (1.) to define translation initiation complexes that mediate stress-specific mRNA translation; (2.) to define and characterize novel substrates of cullin-RING ubiquitin ligases, and (3.) to integrate large scale mRNA and protein expression datasets into a systems view of oxidative stress response. We are also applying insights derived from our studies in fission yeast to the biology of human cancer. In particular, we are seeking ubiquitin ligases targeting several tumor suppressor proteins involved in prostate cancer. We are also performing high-throughput screens for small molecule inhibitors of ectopic degradation of prostate tumor suppressors.
About Dieter Wolf
Dieter Wolf obtained an M.D. degree from the Ludwig-Maximilian’s University in Munich, Germany in 1995. Upon postdoctoral work at Harvard Medical School and Stanford University School of Medicine, he joined the faculty of the Harvard School of Public Health in 1998 as an Assistant Professor advancing to Associate Professor in 2003. In 2007, Dr. Wolf was recruited to Sanford-Burnham Medical Research Institute as Professor in the Signal Transduction Program and Director of the NCI-designated Cancer Center Proteomics Facility.