|
|
|
|
Apoptosis & Cell Death Research
true
10000
-
3D look at protein family with a long Sanford-Burnham history
Structural biologists Drs. Stefan Riedl and Peter Mace answer several perplexing questions about Cas proteins—a family of cancer-related proteins that's long been studied at Sanford-Burnham.
-
Mechanism that promotes lung cancer growth
Dr. John Reed and collaborators uncovered a new mechanism that may lead to unique treatments for lung cancer.
-
Meet a cancer researcher
Meet Dr. Guy Salvesen, professor and director of the Apoptosis & Cell Death Program in Sanford-Burnham’s NCI-designated Cancer Center.
|
|
Studying apoptosis and cell death
Researchers in the Apoptosis and Cell Death Research Program investigate the fundamental molecular mechanisms that control cell death and survival. Research in this program brings together the talents of molecular and cellular biologists, protein biochemists, chemists, structural biologists, computational biologists and more—in a highly interactive way. Discoveries by scientists in this program have led to the development of DNA-based and small molecule-based therapeutics that target anti-death genes and proteins in cancer cells, making them easier to kill with conventional chemotherapy.
Research in the Apoptosis and Cell Death Program helps increase our understanding of human health and identifies new drugs targets for cancer, neurodegeneration, and many other diseases.
|
|
The human body contains cells with different life expectancies. Some, like white blood cells and skin cells, are programmed to rapidly die and be replaced by new cells. Others, such as nerve cells in the brain, are programmed to survive the lifetime of the individual and are seldom replaced. The naturally occurring turnover of cells in the body is called programmed cell death, or apoptosis.
All cells are endowed with this genetic program for self-destruction in order to balance cell production with cell loss.
How our research helps improve health
Defects in apoptosis occur commonly in disease—it is estimated that defects in the program controlling cell lifespan are implicated in over half of the major medical illnesses for which there or no cures or prevention strategies. Too much cell death can result in untimely brain cell death (as in neurodegenerative conditions like Alzheimer’s disease), while too little cell death contributes to the cell accumulation seen in tumors.
Research - Cancer - Apoptosis: How Our Research Helps |
|
|
-
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Gerlic M, Faustin B, Postigo A, Yu EC, Proell M, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, Matsuzawa S, Reed JC.
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13. doi: 10.1073/pnas.1215995110. Epub 2013 Apr 19.
Read More
-
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Mace PD, Wallez Y, Egger MF, Dobaczewska MK, Robinson H, Pasquale EB, Riedl SJ.
Nat Commun. 2013 Apr 9;4:1681. doi: 10.1038/ncomms2687.
Read More
-
The discreet charm of the curve.
Marassi FM.
Biophys J. 2013 Mar 19;104(6):1215-6. doi: 10.1016/j.bpj.2013.01.046. Epub 2013 Mar 19.
Read More
-
Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein.
Wilkie-Grantham RP, Matsuzawa S, Reed JC.
J Biol Chem. 2013 May 3;288(18):12777-90. doi: 10.1074/jbc.M112.431320. Epub 2013 Mar 21.
Read More
-
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J.
Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028.
Read More
-
Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP.
Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.
ACS Chem Biol. 2013 Apr 19;8(4):725-32. doi: 10.1021/cb3005512. Epub 2013 Feb 5.
Read More
View All Publications
Research - Cancer - Apoptosis: Recent Publications |
|
Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling.
Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC
PLoS One. 2013;8(5):e64256
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Gerlic M, Faustin B, Postigo A, Yu EC, Proell M, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, Matsuzawa S, Reed JC
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J
Cell. 2013 Jan 31;152(3):599-611
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.
Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND
ACS Chem Biol. 2013 Apr 19;8(4):725-32
Targeting the Bcl-2 family for cancer therapy.
Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB
Expert Opin Ther Targets. 2013 Jan;17(1):61-75
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.
Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, Xu H
J Neurosci. 2012 Oct 31;32(44):15565-76
View All Publications
|
|
|
|
|
|